Louisiana Tech Faculty Information Page

DeCoster, Dr. Mark A.

Associate Professor of Biomedical Engineering

Degrees

PhD-Biochemistry and Molecular Biophysics: Medical College of Virginia/VCU

BS-Biology: College of William and Mary

Contact Info

Office: 212 Institute for Micromanufacturing (IFM)
Email: decoster@latech.edu

Phone: (318) 257-5118
Home Page: Under Construction

Areas of Specialization

Cellular Neuroscience
Calcium Imaging
Lipid Signaling

Research Areas/Interests

Integration of cells of the nervous system and nanotechnology/nanomaterials
Secreted phospholipase A₂ (sPLA₂)
Neuronal cell injury

Selected Publications

Wu, W., DeCoster, M.A., Daniel, B.M., Chen, J.F., Yu, M.H., Cruntu, D., O’Connor, C.J., and Zhou, W.L. “One-step synthesis of magnetic hollow silica and their application for nanomedicine” J. Applied Physics 99 (2006) 08H104.

Mohammed, J.S., DeCoster, M.A., McShane, M.J. “Fabrication of Interdigitated Micropatterns of Self-Assembled Polymer Nanofilms Containing Cell adhesive Materials” Langmuir 22 (2006) 2738-46 .

Wang, G., Daniel, B.M, and DeCoster, M.A. “Role of nitric oxide in regulating release of sPLA₂ from astrocytes.” NeuroReport 16 (2005) 1345-50.

Mohammed, J.S., DeCoster, M.A., McShane, M.J. “Micropatterning of nanoengineered surfaces to study neuronal cell attachment in vitro.” Biomacromolecules 5 (2004) 1745-55.

Daniel, B. and DeCoster, M.A. Quantification of sPLA₂-induced early and late apoptosis changes in neuronal cell cultures using combined TUNEL and DAPI staining. Brain Res. Protoc. 13 (2004) 144-50.

Zhu, P., DeCoster, M.A., Bazan, N.G. Interplay Among Platelet-Activating Factor (PAF), Oxidative Stress, and Group I Metabotropic Glutamate Receptor Modulates Neuronal Survival. J. Neuroscience Research, 77 (2004) 525-31.

DeCoster, M.A. Group III secreted phospholipase A2 causes apoptosis in rat primary cortical neuronal cultures. Brain Res. 988 (2003) 20-28.

Rodriguez De Turco EB, Jackson FR, DeCoster M.A., Kolko M, Bazan NG. Glutamate signalling and secretory phospholipase A2 modulate the release of arachidonic acid from neuronal membranes. J Neurosci Res 68 (2002) 558-567.

DeCoster M.A., Lambeau G., Lazdunski M., and Bazan N.G. Secreted phospholipase A₂ potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures. J. Neurosci. Res. 67 (2002) 634-645.

Jeanclos E.M., Lin L., Treuil M.M., Jayaraman A., DeCoster M.A., and Anand R. The chaperone protein 14-3-3η interacts with the nicotinic acetylcholine receptor α4 subunit: evidence for a role in subunit stabilization. J. Biol. Chem., 276 (2001) 28281-28290.

Serou M. J., DeCoster M.A., and Bazan N.G. Interleukin-1 beta induces cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression. J. Neurosci. Res., 58 (1999) 593-598.

DeCoster M.A., Schabelman E., Tombran-Tink J., and Bazan N. G. Neuroprotection by Pigment Epithelium-Derived Factor (PEDF) against Glutamate Toxicity in Developing Primary Hippocampal Neurons. J. Neurosci. Res., 56 (1999) 604-610.

Mukherjee* P.K., DeCoster* M.A., Campbell F.Z., Davis R.J., and Bazan, N.G. Glutamate receptor signaling interplay modulates stress‑sensitive Mitogen-activated Protein Kinases and Neuronal Cell Death. *Both authors contributed equally to this paper. J. Biol. Chem., 274 (1999) 6493-6498.

Ogden F., DeCoster M.A., and Bazan N.G. Recombinant plasma‑type platelet‑activating factor acetylhydrolase attenuates NMDA‑induced hippocampal neuronal apoptosis. J. Neurosci. Res., 53 (1998) 677-684.

DeCoster M.A., Mukherjee P.K., Davis R.J. and Bazan, N.G. Platelet-activating factor is a downstream messenger of kainate-induced activation of MAP kinases in primary hippocampal neurons. J. Neurosci. Res., 53 (1998) 297-303.

Klette, K. L., Lin, Y., Clapp, L. E., DeCoster, M. A., Moreton, J. E., and Tortella, F. C.: Neuroprotective Sigma Ligands Attenuate NMDA and trans-ACPD Induced Calcium Signaling in Rat Primary Neurons. Brain Res. 756 (1997) 231-240.

Kolko, M., DeCoster, M. A., Rodriquez de Turco, E. B., Bazan, N. G.: Synergy by secretory phospholipase A₂ and glutamate on inducing cell death and sustained arachidonic acid metabolic changes in primary cortical neuronal cultures. J. Biological Chemistry 271 #51 (1996) 32722-28.

Yourick, D. L. and DeCoster, M. A.: Acute and chronic effects of estrogenic compounds on glutamate-stimulated phosphatidylinositol metabolism in primary neuronal cultures. Neuroscience Letters 206 (1996) 145-148.

Klette, K. L., DeCoster, M. A., Moreton, J. E., and Tortella, F. C.: Role of calcium in sigma-mediated neuroprotection against glutamate in vitro. Brain Research 704 (1995) 31-41.

Tortella, F. C., Klette, K. L., DeCoster, M. A., Davis, B. J., and Newman, A. H.: Dextromethorphan analogs are neuroprotective in vitro and block glutamate-induced excitotoxic calcium signals in neurons. Neuroscience Letters 198 (1995) 79-82.

DeCoster, M. A.: Calcium Dynamics in the Central Nervous System. (Review) Advances in Neuroimmunology 5 (1995) 233-239.

Clapp, L. E., Klette, K. L., DeCoster, M. A., Bernton, E., Petras, J. M., Dave, J. R., Laskosky, M. S., Smallridge, R. C., and Tortella, F. C.: Phospholipase A₂ induced neurotoxicity in vitro and in vivo in rats. Brain Research 693 (1995) 101-111.

DeCoster, M. A., Klette, K. L., Knight, E. S., and Tortella, F. C.: Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures. Brain Research 671(1995) 45-53.

DeCoster, M. A., Conover, J. R., Hunter, J. C., and Tortella, F. C.: The neuroprotective κ-opioid CI-977 alters glutamate-induced calcium signalling in vitro. NeuroReport 5 (1994) 2305-2310.

Tortella, F. C. and DeCoster, M. A.: Kappa opioids: therapeutic considerations in epilepsy and CNS injury. (Review) Clinical Neuropharmacology 17 (1994) 403-416.

DeCoster, M. A. and Yourick, D. L.: Development of glutamate-stimulated phosphatidylinositol metabolism in primary neuronal and astrocyte cultures. International Journal of Developmental Neuroscience, 12 (1994) 227-233.

DeCoster, M. A., Koenig, M. L., Hunter, J. C., and Tortella, F. C.: Calcium dynamics in neurons treated with toxic and non‑toxic concentrations of glutamate. NeuroReport, 3 (1992) 773‑776.